Abstract
Hispanolone is a furolabdane diterpene isolated from Ballota hispanica, whose natural product chemistry has been summarized and updated here, including several aspects associated with the isolation, structure determination, hemisynthesis, total synthesis, and pharmacology, and related hispanolone diterpenoids that have attracted the interest of different laboratories from diverse perspective and expertise in the last forty-two years.
Keywords:
Ballota genus; Diterpenes; Hemisynthesis; Hispanolone; Isolation; Labiatae family; Natural products; Pharmacology; Reactivity; Total synthesis.
Copyright © 2020 Elsevier Ltd. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Ballota / chemistry*
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Humans
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Molecular Conformation
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Biological Products
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Diterpenes
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Enzyme Inhibitors
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hispanolone